Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.

Bibliographic Details
Main Authors: Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07012-4

Internet

https://doi.org/10.1038/s41467-018-07012-4

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