Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.

Bibliographic Details
Main Authors:	Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07012-4

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spelling	doaj-ea828c6ee26840cd8de08621cb5f0b7d2021-05-11T10:05:11ZengNature Publishing GroupNature Communications2041-17232018-11-019111110.1038/s41467-018-07012-4Competing protein-protein interactions regulate binding of Hsp27 to its client protein tauRebecca Freilich0Miguel Betegon1Eric Tse2Sue-Ann Mok3Olivier Julien4David A. Agard5Daniel R. Southworth6Koh Takeuchi7Jason E. Gestwicki8Department of Pharmaceutical Chemistry, University of California San FranciscoDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartment of Pharmaceutical Chemistry, University of California San FranciscoDepartment of Pharmaceutical Chemistry, University of California San FranciscoDepartment of Biochemistry and Biophysics, University of California San FranciscoDepartment of Biochemistry and Biophysics, University of California San FranciscoMolecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)Department of Pharmaceutical Chemistry, University of California San FranciscoSmall heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.https://doi.org/10.1038/s41467-018-07012-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rebecca Freilich Miguel Betegon Eric Tse Sue-Ann Mok Olivier Julien David A. Agard Daniel R. Southworth Koh Takeuchi Jason E. Gestwicki
spellingShingle	Rebecca Freilich Miguel Betegon Eric Tse Sue-Ann Mok Olivier Julien David A. Agard Daniel R. Southworth Koh Takeuchi Jason E. Gestwicki Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau Nature Communications
author_facet	Rebecca Freilich Miguel Betegon Eric Tse Sue-Ann Mok Olivier Julien David A. Agard Daniel R. Southworth Koh Takeuchi Jason E. Gestwicki
author_sort	Rebecca Freilich
title	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_short	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_full	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_fullStr	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_full_unstemmed	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_sort	competing protein-protein interactions regulate binding of hsp27 to its client protein tau
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-11-01
description	Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.
url	https://doi.org/10.1038/s41467-018-07012-4
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Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

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