Excess TGF-β1 Drives Cardiac Mesenchymal Stromal Cells to a Pro-Fibrotic Commitment in Arrhythmogenic Cardiomyopathy

Excess TGF-β1 Drives Cardiac Mesenchymal Stromal Cells to a Pro-Fibrotic Commitment in Arrhythmogenic Cardiomyopathy

Arrhythmogenic Cardiomyopathy (ACM) is characterized by the replacement of the myocardium with fibrotic or fibro-fatty tissue and inflammatory infiltrates in the heart. To date, while ACM adipogenesis is a well-investigated differentiation program, ACM-related fibrosis remains a scientific gap of kn...

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Bibliographic Details
Main Authors: Angela Serena Maione, Ilaria Stadiotti, Chiara Assunta Pilato, Gianluca Lorenzo Perrucci, Valentina Saverio, Valentina Catto, Giulia Vettor, Michela Casella, Anna Guarino, Gianluca Polvani, Giulio Pompilio, Elena Sommariva
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
arrhythmogenic cardiomyopathy
cardiac- mesenchymal stromal cells
fibrosis
TGF-β1
cardiac remodeling
Online Access:https://www.mdpi.com/1422-0067/22/5/2673

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https://www.mdpi.com/1422-0067/22/5/2673

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