Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes

Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes

The hepatotoxicity of acetaminophen (APAP) occurs by initial metabolism to N-acetyl-p-benzoquinone imine which depletes GSH and forms APAP-protein adducts. Subsequently, the reactive nitrogen species peroxynitrite is formed from nitric oxide (NO) and superoxide leading to 3-nitrotyrosine in proteins...

Full description

Bibliographic Details
Main Authors: Sudip Banerjee, Stepan B. Melnyk, Kimberly J. Krager, Nukhet Aykin-Burns, Sandra S. McCullough, Laura P. James, Jack A. Hinson
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Toxicology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750017300100

Internet

http://www.sciencedirect.com/science/article/pii/S2214750017300100

Similar Items