TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction

TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction

Transforming growth factor β (TGF-β) signaling transduces immunosuppressive biochemical and mechanical signals in the tumor microenvironment. In addition to canonical SMAD transcription factor signaling, TGF-β can promote tumor growth and survival by inhibiting proinflamma...

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Bibliographic Details
Main Authors: Robert L. Furler, Douglas F. Nixon, Christine A. Brantner, Anastas Popratiloff, Christel H. Uittenbogaart
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Cancers
Subjects:
TGF-β
cancer
immunosuppression
TAK1
mechanobiology
extracellular matrix
tensegrity
DNA damage
Online Access:http://www.mdpi.com/2072-6694/10/6/199

Internet

http://www.mdpi.com/2072-6694/10/6/199

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