Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion

Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion

Abstract Background Lymphocyte-activation gene (LAG)3 is a 498 aa transmembrane type I protein acting as an immune inhibitory receptor. It is expressed on activated lymphocytes, natural killer cells and plasmacytoid dendritic cells. In activated lymphocytes, LAG3 expression is involved in negative c...

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Bibliographic Details
Main Authors: Alessandro Ascione, Claudia Arenaccio, Alessandra Mallano, Michela Flego, Mara Gellini, Mauro Andreotti, Craig Fenwick, Giuseppe Pantaleo, Stefano Vella, Maurizio Federico
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Biotechnology
Subjects:
LAG3
Single-chain variable fragment
Phage display
Reconstituted scFv
CD8+ T lymphocytes
Lymphocyte exhaustion
Online Access:http://link.springer.com/article/10.1186/s12896-019-0559-x

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http://link.springer.com/article/10.1186/s12896-019-0559-x

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