Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity.

Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity.

Microgravity decreases osteoblastic activity, induces actin microfilament disruption and inhibits the responsiveness of osteoblast to cytokines, but the mechanisms remains enigmatic. The F-actin cytoskeleton has previously been implicated in manifold changes of cell shape, function and signaling obs...

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Bibliographic Details
Main Authors: Zhongquan Dai, Feng Wu, Jian Chen, Hongjie Xu, Honghui Wang, Feima Guo, Yingjun Tan, Bai Ding, Jinfu Wang, Yumin Wan, Yinghui Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3651164?pdf=render

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http://europepmc.org/articles/PMC3651164?pdf=render

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