N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor1[S]

N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor1[S]

Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits MPO-mediated hypochlorous acid (HOCl) formation a...

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Bibliographic Details
Main Authors: Hao Zhang, Xigang Jing, Yang Shi, Hao Xu, Jianhai Du, Tongju Guan, Dorothee Weihrauch, Deron W. Jones, Weiling Wang, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard, Jr.
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
lipid peroxidation
hypochlorous acid
nitrogen dioxide
nitration
chlorination
low density lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350537

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http://www.sciencedirect.com/science/article/pii/S0022227520350537

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