Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer

Abstract The evolutionary dynamics of tumor‐associated neoantigens carry information about drug sensitivity and resistance to the immune checkpoint blockade (ICB). However, the spectrum of somatic mutations is highly heterogeneous among patients, making it difficult to track neoantigens by circulati...

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Bibliographic Details
Main Authors: Qingzhu Jia, Luting Chiu, Shuangxiu Wu, Jian Bai, Lina Peng, Linpeng Zheng, Rui Zang, Xueqin Li, Bibo Yuan, Yixing Gao, Dingyong Wu, Xiaohong Li, Lin Wu, Jianguo Sun, Ji He, Bruce W. S. Robinson, Bo Zhu
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Advanced Science
Subjects:
ctDNA sequencing
immune checkpoint blockade
neoantigens
non‐small cell lung cancer
personalized medicine
Online Access:https://doi.org/10.1002/advs.201903410

Internet

https://doi.org/10.1002/advs.201903410

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