A central role for P2X7 receptors in human microglia

A central role for P2X7 receptors in human microglia

Abstract Background The ATP-gated ionotropic P2X7 receptor (P2X7R) has the unusual ability to function as a small cation channel and a trigger for permeabilization of plasmalemmal membranes. In murine microglia, P2X7R-mediated permeabilization is fundamental to microglial activation, proliferation,...

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Bibliographic Details
Main Authors: Laura Janks, Cristian V. R. Sharma, Terrance M. Egan
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Ligand-gated ion channel
Purinergic receptor
Permeabilization
Dye uptake
Inflammation
Innate immunity
Online Access:http://link.springer.com/article/10.1186/s12974-018-1353-8

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http://link.springer.com/article/10.1186/s12974-018-1353-8

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