Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity

The effects of atorvastatin on the expression of the hepatic HMG-CoA reductase and LDL receptor genes were investigated in rats. Like the other statins, atorvastatin increased the rate of degradation and presumably cycling of the hepatic LDL receptor. In atorvastatin-treated rats, the half-life of t...

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Bibliographic Details
Main Authors: Gene C. Ness, Christopher M. Chambers, Dayami Lopez
Format: Article
Language:English
Published: Elsevier 1998-01-01
Series:Journal of Lipid Research
Subjects:
atorvastatin
lovastatin
HMG-CoA reductase inhibitors
immunoblotting
Northern blotting
LDL receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752034205X

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http://www.sciencedirect.com/science/article/pii/S002222752034205X

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