DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.

DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.

Cholangiocarcinoma (CCA) is a cancer arising from the neoplastic transformation of cholangiocytes. During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Zebularine (1-(β-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one...

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Bibliographic Details
Main Authors: Kazuaki Nakamura, Kazuhiko Nakabayashi, Kyaw Htet Aung, Kazuko Aizawa, Naoko Hori, Junji Yamauchi, Kenichiro Hata, Akito Tanoue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370694?pdf=render

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http://europepmc.org/articles/PMC4370694?pdf=render

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