The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord

The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord

The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis. Bcl-2 homology-3 domain (BH3)-only proteins are pro-apoptotic members of the Bcl-2 family whose enhanc...

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Bibliographic Details
Main Authors: Nathan Duval, Whitney A. Sumner, Anna G. Andrianakos, Josie J. Gray, Ron J. Bouchard, Heather M. Wilkins, Daniel A. Linseman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
SOD1 G93A transgenic mice
Bcl-2
BH3-only proteins
glial cells
motor neurons
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00015/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00015/full

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