Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using an ex-vivo model, show that cancer-associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase-independent manner, likely by pulling and stretching the basement membrane to...

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Bibliographic Details
Main Authors: Alexandros Glentis, Philipp Oertle, Pascale Mariani, Aleksandra Chikina, Fatima El Marjou, Youmna Attieh, Francois Zaccarini, Marick Lae, Damarys Loew, Florent Dingli, Philemon Sirven, Marie Schoumacher, Basile G. Gurchenkov, Marija Plodinec, Danijela Matic Vignjevic
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00985-8

Internet

https://doi.org/10.1038/s41467-017-00985-8

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