Establishment of Synergistic Chemoimmunotherapy for Head and Neck Cancer Using Peritumoral Immature Dendritic Cell Injections and Low-Dose Chemotherapies

The lack of available tumor antigens with strong immunogenicity, human leukocyte antigen restriction, and immunosuppression via regulatory T-cells (Tregs) and myeloid-derived suppressor cells are limitations for dendritic cell (DC)–based immunotherapy in patients with advanced head and neck cancer (...

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Bibliographic Details
Main Authors: Hiroki Ishii, Kazuaki Chikamatsu, Satoshi Igarashi, Hideyuki Takahashi, Kaname Sakamoto, Hiroji Higuchi, Shota Tanaka, Tomokazu Matsuoka, Keisuke Masuyama
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523317304242