In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation

In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation

Germinal center (GC) B cell differentiation is critical for the production of affinity-matured pathogen-specific antibodies, the dysregulation of which may lead to humoral immunodeficiency or autoimmunity. The development of an in vivo screening system for factors regulating GC B cell differentiatio...

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Bibliographic Details
Main Authors: Rongqing Zhao, Huihui Zhang, Yan Zhang, Dan Li, Chuanxin Huang, Fubin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
germinal center B cell
in vivo screen
shRNA
GC selection
Zdhhc2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01025/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01025/full

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