CD133 Modulate HIF-1α Expression under Hypoxia in EMT Phenotype Pancreatic Cancer Stem-Like Cells

CD133 Modulate HIF-1α Expression under Hypoxia in EMT Phenotype Pancreatic Cancer Stem-Like Cells

Although CD133 is a known representative cancer stem cell marker, its function in tumor aggressiveness under hypoxia is not fully known. The aim of this study is to demonstrate that CD133 regulates hypoxia inducible factor (HIF)-1α expression with tumor migration. The CD133+ pancreatic cancer cell l...

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Bibliographic Details
Main Authors: Koki Maeda, Qiang Ding, Makoto Yoshimitsu, Taisaku Kuwahata, Yumi Miyazaki, Koichirou Tsukasa, Tomomi Hayashi, Hiroyuki Shinchi, Shoji Natsugoe, Sonshin Takao
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic cancer
CD133
cancer stem cell
HIF-1α
hypoxia
migration
EMT
Online Access:http://www.mdpi.com/1422-0067/17/7/1025

Internet

http://www.mdpi.com/1422-0067/17/7/1025

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