Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.

The second messenger cAMP stimulates cellular gene expression via the PKA-mediated phosphorylation of the transcription factor CREB and through dephosphorylation of the cAMP-responsive transcriptional coactivators (CRTCs). Under basal conditions, CRTCs are phosphorylated by members of the AMPK famil...

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Bibliographic Details
Main Authors: Tim Sonntag, James J Moresco, Joan M Vaughan, Shigenobu Matsumura, John R Yates, Marc Montminy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5325614?pdf=render

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http://europepmc.org/articles/PMC5325614?pdf=render

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