In vivo modulation of endothelial polarization by Apelin receptor signalling

Endothelial cells align in the direction of flow in response to shear stress. Here the authors describe a zebrafish model for visualization of endothelial polarization and demonstrate that endothelial cell alignment depends on blood flow and Apelin signalling.

Bibliographic Details
Main Authors: Hyouk-Bum Kwon, Shengpeng Wang, Christian S. M. Helker, S. Javad Rasouli, Hans-Martin Maischein, Stefan Offermanns, Wiebke Herzog, Didier Y. R. Stainier
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11805