Dual-Antigen COVID-19 Vaccine Subcutaneous Prime Delivery With Oral Boosts Protects NHP Against SARS-CoV-2 Challenge

Dual-Antigen COVID-19 Vaccine Subcutaneous Prime Delivery With Oral Boosts Protects NHP Against SARS-CoV-2 Challenge

We have developed a dual-antigen COVID-19 vaccine incorporating genes for a modified SARS-CoV-2 spike protein (S-Fusion) and the viral nucleocapsid (N) protein with an Enhanced T-cell Stimulation Domain (N-ETSD) to increase the potential for MHC class II responses. The vaccine antigens are delivered...

Full description

Bibliographic Details
Main Authors: Elizabeth Gabitzsch, Jeffrey T. Safrit, Mohit Verma, Adrian Rice, Peter Sieling, Lise Zakin, Annie Shin, Brett Morimoto, Helty Adisetiyo, Raymond Wong, Ashish Bezawada, Kyle Dinkins, Joseph Balint, Victor Peykov, Hermes Garban, Philip Liu, Andrew Bacon, Pete Bone, Jeff Drew, Daniel C. Sanford, Patricia Spilman, Lennie Sender, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
non-human primate (NHP)
vaccine
dual antigen
COVID-19
SARS-CoV-2 challenge
protection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full

Similar Items