In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library

In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library

Aptamers are widely used in numerous biochemical, bioanalytical, and biological studies. Most aptamers are developed through an in vitro selection process called SELEX against either purified targets or living cells expressing targets of interest. We report here an in vivo SELEX in mice using a PEGy...

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Bibliographic Details
Main Authors: Hanlu Wang, Yibang Zhang, Haiping Yang, Meng Qin, Xinxin Ding, Rihe Liu, Yongping Jiang
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA aptamer
PEGylated RNA library
NSCLC
NCI-H460
in vivo-SELEX
targeting and inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117303013

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http://www.sciencedirect.com/science/article/pii/S2162253117303013

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