Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF

Background: In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme outcomes. Methods: We randomly allocated 20 laboratories (clus...

Full description

Bibliographic Details
Main Authors: Dr. Gavin J Churchyard, PhD, Wendy S Stevens, FCPath, Lerole D Mametja, MPH, Kerrigan M McCarthy, FCPath, Violet Chihota, PhD, Mark P Nicol, FCPath, Linda K Erasmus, MMed, Norbert O Ndjeka, MMed, Lindiwe Mvusi, MBBCh, Anna Vassall, PhD, Edina Sinanovic, PhD, Helen S Cox, PhD, Christopher Dye, DPhil, Alison D Grant, PhD, Katherine L Fielding, PhD
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:The Lancet Global Health
Online Access:http://www.sciencedirect.com/science/article/pii/S2214109X1500100X