Thrombin generation capacity of prothrombin complex concentrate in an in vitro dilutional model.

BACKGROUND: The use of PCC for the treatment of trauma-induced coagulopathy potentially increase the risk of thromboembolism and disseminated intravascular coagulation, which is addressed to an imbalance of both pro- and anticoagulants. As PCCs differ in composition, we used an in vitro dilutional a...

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Bibliographic Details
Main Authors: Oliver Grottke, Rolf Rossaint, Yvonne Henskens, Rene van Oerle, Hugo Ten Cate, Henri M H Spronk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3656958?pdf=render