Biological Characteristics of Severe Combined Immunodeficient Mice Produced by CRISPR/Cas9-Mediated Rag2 and IL2rg Mutation

Biological Characteristics of Severe Combined Immunodeficient Mice Produced by CRISPR/Cas9-Mediated Rag2 and IL2rg Mutation

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas)9 is a novel and convenient gene editing system that can be used to construct genetically modified animals. Recombination activating gene 2 (Rag2) is a core component that is involved in the initiation of V(D)J...

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Bibliographic Details
Main Authors: Yong Zhao, Peijuan Liu, Zhiqian Xin, Changhong Shi, Yinlan Bai, Xiuxuan Sun, Ya Zhao, Xiaoya Wang, Li Liu, Xuan Zhao, Zhinan Chen, Hai Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
Rag2
IL2rg
CRISPR/Cas9
severe combined immunodeficient mice
biological characteristic
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00401/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00401/full

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