PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase

PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase

The helicase portion of the hepatitis C virus nonstructural protein 3 (NS3) is considered one of the most validated targets for developing direct acting antiviral agents. We isolated polybrominated diphenyl ether (PBDE) 1 from a marine sponge as an NS3 helicase inhibitor. In this study, we evaluated...

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Bibliographic Details
Main Authors: Kazi Abdus Salam, Atsushi Furuta, Naohiro Noda, Satoshi Tsuneda, Yuji Sekiguchi, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Hidenori Tani, Sona Rani Roy, Junichi Tanaka, Masayoshi Tsubuki, Nobuyoshi Akimitsu
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
hepatitis C virus
NS3 RNA helicase
marine sponge
polybrominated diphenyl ether
Online Access:http://www.mdpi.com/1420-3049/19/4/4006

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http://www.mdpi.com/1420-3049/19/4/4006

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