PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase

PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase

The helicase portion of the hepatitis C virus nonstructural protein 3 (NS3) is considered one of the most validated targets for developing direct acting antiviral agents. We isolated polybrominated diphenyl ether (PBDE) 1 from a marine sponge as an NS3 helicase inhibitor. In this study, we evaluated...

Full description

Bibliographic Details
Main Authors:	Kazi Abdus Salam, Atsushi Furuta, Naohiro Noda, Satoshi Tsuneda, Yuji Sekiguchi, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Hidenori Tani, Sona Rani Roy, Junichi Tanaka, Masayoshi Tsubuki, Nobuyoshi Akimitsu
Format:	Article
Language:	English
Published:	MDPI AG 2014-04-01
Series:	Molecules
Subjects:	hepatitis C virus NS3 RNA helicase marine sponge polybrominated diphenyl ether
Online Access:	http://www.mdpi.com/1420-3049/19/4/4006

Similar Items

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase
by: Atsushi Furuta, et al.
Published: (2015-08-01)

Identification and Biochemical Characterization of Halisulfate 3 and Suvanine as Novel Inhibitors of Hepatitis C Virus NS3 Helicase from a Marine Sponge
by: Atsushi Furuta, et al.
Published: (2014-01-01)

Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia
by: Naohiro Noda, et al.
Published: (2012-03-01)

Polybrominated diphenyl ether (PBDE) and poly- and perfluoroalkyl substance (PFAS) exposures during pregnancy and maternal depression
by: Ann M. Vuong, et al.
Published: (2020-06-01)

Recent developments in the analysis of polybrominated diphenyl ethers and polybrominated biphenyls in plastic
by: Shao Mingwu, et al.
Published: (2016-09-01)

Brominated natural products at different trophic levels in the Baltic Sea : Identification of polybrominated dioxins, hydroxylated and methoxylated diphenyl ethers
by: Malmvärn, Anna
Published: (2007)

Combined photocatalysis and phytoremediation for efficient treatment of polybromodiphenyl ethers (PBDES)
by: Chow, Ka Lai
Published: (2013)

Polybrominated Diphenyl Ethers (PBDEs) in Indoor Air: Levels and Exposure
by: S Hazrati, et al.
Published: (2005-10-01)

Polybrominated Diphenyl Ethers (PBDEs) in Indoor Air: Levels and Exposure
by: S Hazrati, et al.
Published: (2005-03-01)

Bioaccumulation of polybrominated diphenyl ethers by Tubifex tubifex
by: Boris Kolar, et al.
Published: (2016-08-01)

Inhalation exposure pathways for polybrominated diphenyl ethers : a source to human receptor model for semivolatile organic compounds
by: Waye, Scot Kenyon, 1980-
Published: (2012)

Investigating the Use of Hair to Assess Polybrominated Diphenyl Ether (PBDE) Exposure Retrospectively, and in Male Infants with Genitourinary Tract Malformations
by: Carnevale, Amanda
Published: (2013)

Determination of brominated flame retardants in Jukskei river and the identification of potential pollution sources.
by: Olukunle, O. I.
Published: (2012)

Study of the Photodegradation of PBDEs in Water by UV-LED Technology
by: Meritxell Valentí-Quiroga, et al.
Published: (2021-07-01)

Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood
by: Naomi Azar, et al.
Published: (2021-01-01)

Characterization and Source Identification of Polybrominated Diphenyl Ethers (PBDEs) in Air in Xi’an: Based on a Five-Year Study
by: Lei Ye, et al.
Published: (2019-02-01)

Exposure Assessment of Polybrominated Diphenyl Ethers in Dust – A Study of Potential Exposure and Examination of Concentration Distribution Sieved to Particle Sizes between 500 and 38 µm
by: Anderson, Sarah N
Published: (2012)

Persistent Organic Pollutants (POPs) in the European Union: Analysis of the NORMAN EMPODAT database system
by: Om Prakash Yadav, et al.
Published: (2020-01-01)

Accumulation and translocation of polybrominated diphenyl ethers into plant under multiple exposure scenarios
by: Hongkai Zhu, et al.
Published: (2020-10-01)

Airborne concentrations of Polybrominated diethyl etherin residential homes
by: S. Rahimzadeh, et al.
Published: (2009-07-01)

The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives
by: Francesca Gorini, et al.
Published: (2018-08-01)

Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study
by: Xuemin Zhao, et al.
Published: (2017-03-01)

Release, transformation, and risk factors of polybrominated diphenyl ethers from landfills to the surrounding environments: A review
by: Yifan Zhang, et al.
Published: (2021-12-01)

Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women
by: Abby D. Mutic, et al.
Published: (2021-03-01)

Fast Removal of Polybrominated Diphenyl Ethers from Aqueous Solutions by Using Low-Cost Adsorbents
by: Renin Chang, et al.
Published: (2017-01-01)

Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition
by: Shuzi Ye, et al.
Published: (2021-12-01)

Brominated flame retardant concentrations in office and household dust in South Africa
by: Kefeni, Kebede Keterew.
Published: (2012)

Mixture effects of prenatal exposure to per- and polyfluoroalkyl substances and polybrominated diphenyl ethers on maternal and newborn telomere length
by: Stephanie M. Eick, et al.
Published: (2021-06-01)

PBDEs versus NBFR in wastewater treatment plants: occurrence and partitioning in water and sludge
by: Joyce Cristale, et al.
Published: (2015-06-01)

PHOTODEGRADATION OF LOWER POLYBROMINATED DIPHENYL ETHER CONGENERS IN INDOOR AIR – MODEL STUDIES
by: Amelia Beata Staszowska
Published: (2017-05-01)

The Sequestration of Oxy-Polybrominated Diphenyl Ethers in the Nudibranchs Miamira magnifica and Miamira miamirana
by: Ariyanti S. Dewi, et al.
Published: (2016-10-01)

Developmental Exposure to 2,2′,4,4′-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice
by: Ahmed Khalil, et al.
Published: (2018-09-01)

Dietary and Socio-Demographic Determinants of Serum Persistent Organic Pollutants (POPs) Levels in Pregnant Women in Tehran
by: Bita Eslami, et al.
Published: (2016-12-01)

Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp.
by: Yuusuke Fujimoto, et al.
Published: (2012-01-01)

Retardantes de chama bromados: uma revisão
by: Michelle C. Pieroni, et al.

Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco
by: Stephanie M. Eick, et al.
Published: (2020-09-01)

Early-life chemical exposures and risk of metabolic syndrome
by: De Long NE, et al.
Published: (2017-03-01)

Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication
by: Iris V Hood, et al.
Published: (2016-05-01)

The replicative CMG helicase: the ideal target for cancer therapy
by: W. Henderson, et al.
Published: (2020-12-01)

BIOACCUMULATION, TROPHIC MAGNIFICATION, AND MATERNAL TRANSFER OF LEGACY AND ALTERNATIVE FLAME RETARDANTS IN SHARKS OF THE NORTHWESTERN ATLANTIC OCEAN
by: Marler, Hillary Rose
Published: (2019)

Cannot write session to /tmp/vufind_sessions/sess_94633c2chs66m5nj7ivqm31anq