Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension

Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension

The paper aimed to progress an ideal gastro retentive drug delivery system intended for directing Losartan and Hydrochlorothiazide as a fixed-dose combination for anti-hypertensive therapy. The bilayer tablets were primed through direct compression method. Losartan was formulated by means of a float...

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Bibliographic Details
Main Authors: Balaji Maddiboyina, Mudavath Hanumanaik, Ramya Krishna Nakkala, Vikas Jhawat, Pinki Rawat, Aftab Alam, Ahmed I. Foudah, Majed M. Alrobaian, Rahul Shukla, Sima Singh, Prashant Kesharwani
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Heliyon
Subjects:
Bi-layer floating tablets
Optimization
Superdisintegrants
Release-retarding polymers
Drug delivery
Pharmaceutical science
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020323021

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http://www.sciencedirect.com/science/article/pii/S2405844020323021

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