Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investi...

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Bibliographic Details
Main Authors: Emily J Lodge, Alice Santambrogio, John P Russell, Paraskevi Xekouki, Thomas S Jacques, Randy L Johnson, Selvam Thavaraj, Stefan R Bornstein, Cynthia Lilian Andoniadou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
pituitary stem cell
SOX2
Hippo
YAP
pituitary tumour
LATS
Online Access:https://elifesciences.org/articles/43996

Internet

https://elifesciences.org/articles/43996

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