GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies

GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies

Abstract Background Autoantibodies against the smaller isoform of glutamate decarboxylase (GAD65Ab) reflect autoimmune etiologies in Type 1 diabetes (T1D) and several neurological disorders, including Stiff Person Syndrome (SPS). GAD65Ab are also reported in cases of epilepsy, indicating an autoimmu...

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Bibliographic Details
Main Authors: Suvi Liimatainen, Jerome Honnorat, Sean J. Pittock, Andrew McKeon, Mario Manto, Jared R. Radtke, T1D Exchange Biobank, Christiane S. Hampe
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Autoimmune epilepsy
Type 1 diabetes
GAD65Ab
Epitope mapping
GAD65 enzyme activity
Online Access:http://link.springer.com/article/10.1186/s13023-018-0787-5

Internet

http://link.springer.com/article/10.1186/s13023-018-0787-5

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