The Enigmatic Role of C9ORF72 in Autophagy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and genomics have revealed intronic hexanucleotide repeat expansions in the gene...

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Bibliographic Details
Main Authors: Melissa Nassif, Ute Woehlbier, Patricio A. Manque
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neuroscience
Subjects:
ALS
FTD
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00442/full