A Random Matrix Theory Approach to Denoise Single-Cell Data

Summary: Single-cell technologies provide the opportunity to identify new cellular states. However, a major obstacle to the identification of biological signals is noise in single-cell data. In addition, single-cell data are very sparse. We propose a new method based on random matrix theory to analy...

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Bibliographic Details
Main Authors: Luis Aparicio, Mykola Bordyuh, Andrew J. Blumberg, Raul Rabadan
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Patterns
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666389920300404