Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy

Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy

Background T follicular helper cells (Tfh) are essential to shape B cell response during germinal center formation. Tfh accumulation has been reported in various human cancers, with positive or negative prognostic roles. However, the mechanisms explaining the accumulation of Tfh and their role in ca...

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Bibliographic Details
Main Authors: Valentin Derangere, Marion Thibaudin, Fanny Chalmin, Cédric Rébé, Julie Niogret, Hélène Berger, Romain Mary, Elise Ballot, Christophe Hibos, Léa Hampe, David Rageot, Théo Accogli, Philippe Joubert, James Harker, Frederique Vegran
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/6/e002157.full

Internet

https://jitc.bmj.com/content/9/6/e002157.full

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