Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

The spindle shows remarkable diversity, and changes in an integrated fashion, as cells vary over evolution. Here, we provide a mechanistic explanation for variations in the first mitotic spindle in nematodes. We used a combination of quantitative genetics and biophysics to rule out broad classes of...

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Bibliographic Details
Main Authors: Reza Farhadifar, Che-Hang Yu, Gunar Fabig, Hai-Yin Wu, David B Stein, Matthew Rockman, Thomas Müller-Reichert, Michael J Shelley, Daniel J Needleman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
cell division
mitotic spindle
scaling
QTL mapping
mathematical modeling
cortical forces
Online Access:https://elifesciences.org/articles/55877

Internet

https://elifesciences.org/articles/55877

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