The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

Abstract Background The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1–86). Activation of AC6, rather than AC...

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Bibliographic Details
Main Authors: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen, Yijuang Chern
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Biomedical Science
Subjects:
Type V adenylyl cyclase
AC6
cAMP
STAT3
Microdomain
Online Access:http://link.springer.com/article/10.1186/s12929-017-0367-3

Internet

http://link.springer.com/article/10.1186/s12929-017-0367-3

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