APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome

APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome

The proteasome is a multienzymatic complex that controls the half-life of the majority of intracellular proteins, including those involved in apoptosis and cell-cycle progression. Recently, proteasome inhibition has been shown to be an effective anticancer strategy, although its downregulation is of...

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Bibliographic Details
Main Authors: Rosanna Palumbo, Marta Gogliettino, Ennio Cocca, Roberta Iannitti, Annamaria Sandomenico, Menotti Ruvo, Marco Balestrieri, Mosè Rossi, Gianna Palmieri
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:International Journal of Molecular Sciences
Subjects:
acylpeptide hydrolase (APEH)
proteasome
osteosarcoma cell lines
peptide inhibitor
anti-tumoral target
Online Access:http://www.mdpi.com/1422-0067/17/10/1614

Internet

http://www.mdpi.com/1422-0067/17/10/1614

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