Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

Abstract Background Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets of FKB in prostate cancer cells remain unknown. Methods An in vitro NEDD...

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Bibliographic Details
Main Authors: Xuesen Li, Victor Pham, Matthew Tippin, Dongjun Fu, Raymond Rendon, Liankun Song, Edward Uchio, Bang H. Hoang, Xiaolin Zi
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cell Communication and Signaling
Subjects:
Chalcone
Neddylation
Skp2
And prostate cancer
Online Access:http://link.springer.com/article/10.1186/s12964-019-0338-2

Internet

http://link.springer.com/article/10.1186/s12964-019-0338-2

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