Evaluating Controlled Human Malaria Infection in Kenyan Adults with Varying Degrees of Prior Exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

Evaluating Controlled Human Malaria Infection in Kenyan Adults with Varying Degrees of Prior Exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

Background: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, C...

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Bibliographic Details
Main Authors: Susanne Helena Hodgson, Elizabeth A Juma, Amina eSalim, Charles eMagiri, Domtila eKimani, Daniel eNjenga, Alfred eMuia, Andrew O Cole, Caroline eOgwang, Ken eAwuondo, Brett eLowe, Marianne eMuene, Peter F Billingsley, Eric eJames, Anusha eGunasekera, B Kim. Lee Sim, Patricia eNjuguna, Thomas W Rampling, Adam eRichman, Yonas eAbebe, Gathoni eKamuyu, Michelle eMuthui, B Kim Lee Sim, Sean eElias, Sassy eMolyneux, Stephen eGerry, Alex eMacharia, Thomas N Williams, Peter C Bull, Adrian VS Hill, Faith H Osier, Simon J Draper, Philip eBejon, Stephen L Hoffman, Bernhards eOgutu, Kevin eMarsh
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Microbiology
Subjects:
Immunity
Malaria
challenge
falciparum
CHMI
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00686/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00686/full

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