Drug Metabolite Cluster-Based Data-Mining Method for Comprehensive Metabolism Study of 5-hydroxy-6,7,3′,4′-tetramethoxyflavone in Rats

Drug Metabolite Cluster-Based Data-Mining Method for Comprehensive Metabolism Study of 5-hydroxy-6,7,3′,4′-tetramethoxyflavone in Rats

The screening of drug metabolites in biological matrixes and structural characterization based on product ion spectra is among the most important, but also the most challenging due to the significant interferences from endogenous species. Traditionally, metabolite detection is accomplished primarily...

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Bibliographic Details
Main Authors: Yuqi Wang, Xiaodan Mei, Zihan Liu, Jie Li, Xiaoxin Zhang, Shuang Lang, Long Dai, Jiayu Zhang
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
5-hydroxy-6,7,3′,4′-tetramethoxyflavone (HTF)
metabolites
drug metabolite clusters (DMCs)
ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry
data-mining methods
Online Access:https://www.mdpi.com/1420-3049/24/18/3278

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https://www.mdpi.com/1420-3049/24/18/3278

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