Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes

Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes

Acute kidney injury (AKI) is more frequent in elderly patients. Mechanisms contributing to AKI (tubular cell death, inflammatory cell infiltration, impaired mitochondrial function, and prolonged cell-cycle arrest) have been linked to cellular senescence, a process implicated in regeneration failure...

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Bibliographic Details
Main Authors: Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Laura Santos-Sanchez, Floris A. Valentijn, Elena Cantero-Navarro, Sandra Rayego-Mateos, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Ana B. Sanz, Alberto Ortiz, Roel Goldschmeding, Marta Ruiz-Ortega
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
aging
necroptosis
apoptosis
cellular senescence
inflammation
immunosenescence
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.662020/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.662020/full

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