Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

BACKGROUND:Rhesus macaques are unusual among schistosome hosts, self-curing from an established infection and thereafter manifesting solid immunity against a challenge, an ideal model for vaccine development. Previously, the immunological basis of self-cure was confirmed; surviving worms had ceased...

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Bibliographic Details
Main Authors: Xiao-Hong Li, Yu-Xin Xu, Gill Vance, Yun Wang, Long-Bao Lv, Govert J van Dam, Jian-Ping Cao, R Alan Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4498593?pdf=render