A web tool for designing and conducting phase I trials using the continual reassessment method

Abstract Background Broad implementation of model-based dose-finding methods, such as the continual reassessment method (CRM), has been limited, with traditional or modified 3 + 3 designs remaining in frequent use. Part of the reason is the lack of reliable, easy-to-use, and robust software tools fo...

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Bibliographic Details
Main Authors: Nolan A. Wages, Gina R. Petroni
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12885-018-4038-x