Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1

MuRF1 is an E3 ubiquitin ligase central to muscle catabolism. It belongs to the TRIM protein family characterized by a tripartite fold of RING, B-box and coiled-coil (CC) motifs, followed by variable C-terminal domains. The CC motif is hypothesized to be responsible for domain organization in the fo...

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Bibliographic Details
Main Authors: Barbara Franke, Alexander Gasch, Dayté Rodriguez, Mohamed Chami, Muzamil M. Khan, Rüdiger Rudolf, Jaclyn Bibby, Akira Hanashima, Julijus Bogomolovas, Eleonore von Castelmur, Daniel J. Rigden, Isabel Uson, Siegfried Labeit, Olga Mayans
Format: Article
Language:English
Published: The Royal Society 2014-01-01
Series:Open Biology
Subjects:
rbcc/trim fold
coiled-coil
cos-box
x-ray crystallography
electron microscopy
ab initio modelling
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130172

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130172

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