Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

rQNestin34.5v.2 is an oncolytic herpes simplex virus 1 (oHSV) that retains expression of the neurovirulent ICP34.5 gene under glioma-selective transcriptional regulation. To prepare an investigational new drug (IND) application, we performed toxicology and efficacy studies of rQNestin34.5v.2 in mice...

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Bibliographic Details
Main Authors: E. Antonio Chiocca, Hiroshi Nakashima, Kazue Kasai, Soledad A. Fernandez, Michael Oglesbee
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
herpes simplex virus
ICP34.5
nestin, oncolytic virus, toxicology, glioblastoma, brain tumor, preclinical study
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300589

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http://www.sciencedirect.com/science/article/pii/S2329050120300589

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