Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms

Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms

The molecular basis for epileptogenesis remains poorly defined, but repeated or prolonged seizures can cause altered hippocampal N-methyl d-aspartate receptor (NMDAR) stoichiometry, loss of hippocampal neurons, and aberrant mossy fiber sprouting. Using the muscarinic receptor 1 (m1R) agonist, piloca...

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Bibliographic Details
Main Authors: Roberto Di Maio, Pier G. Mastroberardino, Xiaoping Hu, Laura Montero, J. Timothy Greenamyre
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Oxidative stress
IP3
NADPH oxidase
ERK
NMDA receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000660

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http://www.sciencedirect.com/science/article/pii/S0969996111000660

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