GPER1-mediated immunomodulation and neuroprotection in the myenteric plexus of a mouse model of Parkinson's disease

GPER1-mediated immunomodulation and neuroprotection in the myenteric plexus of a mouse model of Parkinson's disease

Lewy pathology affects the gastrointestinal tract in Parkinson's disease (PD) and recent reports suggest a link between the disorder and gut inflammation. In this study, we investigated enteric neuroprotection and macrophage immunomodulation by 17β-estradiol (E2) and the G protein-coupled estro...

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Bibliographic Details
Main Authors: Mélissa Côté, Mélanie Bourque, Andrée-Anne Poirier, Benoit Aubé, Marc Morissette, Thérèse Di Paolo, Denis Soulet
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
17β-estradiol
GPER1
Ileum
Inflammation
Innate immune response
Intestine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001916

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http://www.sciencedirect.com/science/article/pii/S0969996115001916

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