Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

Abstract Background Whole‐cell phenotypic screening is the driving force behind modern anti‐tubercular drug discovery efforts. Focus has shifted from screening for bactericidal scaffolds to screens incorporating target deconvolution. Target‐based screening aims to direct drug discovery toward known...

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Bibliographic Details
Main Authors: Christopher Burke, Monika Jankute, Patrick Moynihan, Ruben Gonzalez del Rio, Xiaojun Li, Jorge Esquivias, Joël Lelièvre, Jonathan A. G. Cox, James Sacchettini, Gurdyal S. Besra
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:FASEB BioAdvances
Subjects:
mCherry
mycobacteria
ribosome
RNA polymerase
transcription
translation
Online Access:https://doi.org/10.1096/fba.2020-00022

Internet

https://doi.org/10.1096/fba.2020-00022

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