Designing siRNA that distinguish between genes that differ by a single nucleotide.

Designing siRNA that distinguish between genes that differ by a single nucleotide.

Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that specifically silence the mutant disease allele, whi...

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Bibliographic Details
Main Authors: Dianne S Schwarz, Hongliu Ding, Lori Kennington, Jessica T Moore, Janell Schelter, Julja Burchard, Peter S Linsley, Neil Aronin, Zuoshang Xu, Phillip D Zamore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1560399?pdf=render

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http://europepmc.org/articles/PMC1560399?pdf=render

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