Designing siRNA that distinguish between genes that differ by a single nucleotide.
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that specifically silence the mutant disease allele, whi...
Main Authors: | Dianne S Schwarz, Hongliu Ding, Lori Kennington, Jessica T Moore, Janell Schelter, Julja Burchard, Peter S Linsley, Neil Aronin, Zuoshang Xu, Phillip D Zamore |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2006-09-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC1560399?pdf=render |
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