Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice[S]

Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice[S]

Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces FoxO1 phosphorylation, lowers FoxO1 nuclear content, and suppresses expression of genes involved in gluconeogenesis (GNG). In this report, we define the molecular and metabolic basis of Elovl5 control of FoxO1 phosphorylation. Ade...

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Bibliographic Details
Main Authors: Sasmita Tripathy, Donald B. Jump
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Journal of Lipid Research
Subjects:
fatty acid elongase-5
palmitoleic acid
cis-vaccenic acid rictor
gluconeogenesis forkhead box O1
mammalian target of rapamycin complex 2
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520417638

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http://www.sciencedirect.com/science/article/pii/S0022227520417638

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