Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key event in the etiology of AD. We have previously modeled amyloid-beta (Aβ)-induced mitochondrial dysfunction in a transgenic Caenorhabditis elega...

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Bibliographic Details
Main Authors: Emelyne Teo, Sudharshan Ravi, Diogo Barardo, Hyung-Seok Kim, Sheng Fong, Amaury Cazenave-Gassiot, Tsze Yin Tan, Jianhong Ching, Jean-Paul Kovalik, Markus R Wenk, Rudiyanto Gunawan, Philip K Moore, Barry Halliwell, Nicholas Tolwinski, Jan Gruber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
amyloid beta
mitochondria
metformin
TCA cycle
metabolism
Online Access:https://elifesciences.org/articles/50069

Internet

https://elifesciences.org/articles/50069

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